Experimental Ebola drug ZMapp raises issues of fair access
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Experimental Ebola drug ZMapp raises issues of fair access

Experimental Ebola drug ZMapp raises issues of fair access

Health experts urge affected countries to focus on controlling, not curing disease

The Associated Press Posted: Aug 06, 2014

The use of an experimental drug to treat two Americans diagnosed with Ebola is raising ethical questions about who gets first access to unproven new therapies for the deadly disease. But some health experts fear debate over extremely limited doses will distract from tried-and-true measures to curb the growing outbreak — things like more rapidly identifying and isolating the sick.

The World Health Organization is convening a meeting of medical ethicists next week to examine what it calls “the responsible thing to do” about whatever supplies eventually may become available of a medicine that’s never been tested in people.

At least one country involved in the outbreak is interested in the drug. Nigeria’s health minister, Onyenbuchi Chukwu, said at a news conference that he had asked the U.S. Centers for Disease Control and Prevention about access. CDC Director Tom Frieden “conveyed there are virtually no doses available” but basic supportive care can work, a CDC spokesman said Wednesday.

‘The bottom line with Ebola is we know how to stop it: traditional public health.’– Tom Frieden, Director of the U.S. Centers for Disease Control and Prevention

There is no proven treatment or vaccine for Ebola, which so far has infected more than 1,700 people and killed more than 930 in West Africa in what has become the worst outbreak of this viral hemorrhagic fever.

“How many times have we found magic therapies that ended up … doing more harm than good?” cautioned University of Minnesota professor Michael Osterholm, who advises the U.S. government on infectious disease threats.

“Vaccine and drug treatment right now is not going to be the main way you bring this to a stop,” he added.

U.S. President Barack Obama said Tuesday there wasn’t enough information available on the new drug to consider fast-tracking it, and said the U.S. and its health partners are focused on controlling and containing the disease.

Unclear if new treatment works

Ebola American experimental medication

ZMapp, the new experimental drug, is made up of antibodies cultivated in tobacco plants at a facility in Owensboro, Ky. (Kentucky BioProcessing/AP)

Scientists stress that there’s no way to tell if the experimental drug ZMapp really made a difference for two American aid workers infected while working in Liberia.

“We don’t even know if it works,” stressed Dr. Anthony Fauci of the National Institutes of Health, which helped fund research that led to the drug’s development.

The drug is a cocktail of three antibodies engineered to recognize Ebola and bind to infected cells so that the immune system can kill them.

People’s immune systems make antibodies to fight off various diseases, and attempts to cull those antibodies — from the blood of people who survive an illness, or from animals — date back to the 19th century and early diphtheria treatment. Using modern techniques to fight Ebola, scientists culled antibodies from laboratory mice, Fauci said, and ZMapp’s maker now grows the antibodies in tobacco plants and then purifies them.

via Experimental Ebola drug ZMapp raises issues of fair access – Health – CBC News.

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