Groundbreaking Study Finds Turmeric Extract Superior to Prozac for Depression
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Groundbreaking Study Finds Turmeric Extract Superior to Prozac for Depression

Groundbreaking Study Finds Turmeric Extract Superior to Prozac for Depression

Posted on Friday, July 19th 2013

Written By Sayer Ji

English: Curcumin Polski: Kurkumina

English: Curcumin Polski: Kurkumina (Photo credit: Wikipedia)

A new study published in the journal Phytotherapy Research has confirmed for the first time in a randomized, controlled clinical trial that the primary polyphenol in turmeric known as curcumin is both safe and effective in treating serious states of depression.[1]

The research was performed at the Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India, and involved patients diagnosed with major depressive disorder (MDD).  The objective of the trial was to compare the efficacy and safety of curcumin with fluoxetine (Prozac) in 60 patients diagnosed with MDD. Subjects were randomized to receive either a six week treatment with fluoxetine (20 mg) and curcumin (1000 mg) individually or their combination.

Success of the treatment was evaluated using the 17-item Hamilton Depression Rating Scale (HAM-D17). The results were reported as follows:

We observed that curcumin was well tolerated by all the patients. The proportion of responders as measured by the HAM-D17 scale was higher in the combination group (77.8%) than in the fluoxetine [Prozac] (64.7%) and the curcumin (62.5%) groups; however, these data were not statistically significant (P = 0.58). Interestingly, the mean change in HAM-D17 score at the end of six weeks was comparable in all three groups (P = 0.77). This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD without concurrent suicidal ideation or other psychotic disorders. [emphasis added]

Discussion

happy woman on curcumin

If the results of this relatively small trial are applicable to a wider population, this is truly groundbreaking news. There was already a rather sizable body of preclinical research indicating that curcumin is an effective antidepressant in the animal model,[2] but this was not enough to sway most physicians who practice so-called “evidence based medicine” into actually suggesting it to patients as a Prozac or antidepressant alternative. And this is understandable, as the lack of solid human clinical evidence supporting the use of a natural substance is no small matter from a legal-regulatory perspective. Unless a substance has passed through the approximately 800 million dollar financial gauntlet of phase I, II, and III clinical trials required to apply for FDA drug approval, and has actually received that approval, there is scant legal protection for those who use natural medicines to prevent or treat disease and who might face a lawsuit, frivolous or genuine, as a result of a claim of injury.

Curcumin, of course, is extremely safe, with a 2010 phase I safety study finding that oral doses as high as 8 grams a day were well tolerated.[3]  Fluoxetine, on the other hand, is highly controversial due to its well-known toxicity, and its laundry list of side effects, which include suicidal ideation (not a good side effect for someone already depressed!).

via Groundbreaking Study Finds Turmeric Extract Superior to Prozac for.

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